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non phosphorylated control dsrna  (InvivoGen)


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    InvivoGen non phosphorylated control dsrna
    BRRIAR expression and immune activation in patient-derived samples. a High-resolution spatial transcriptomics map of one ER + breast tumor generated using the Curio Seeker platform. b Corresponding BRRIAR -positive cell states. c Spatial neighborhood analysis of BRRIAR -positive cells. Bars represent the proportion of neighbouring cell types within a defined radius. Error bars, SD ( n = 13 cells). p value was determined by Student’s t- test (* p < 0.05). d Scatter plot showing correlation between BRRIAR and RIG-I (left panel) or IRF7 (right panel) expression. Each black dot represents an individual cell at the co-expression peak. A linear regression line with its 95% confidence interval (blue shaded area) is overlaid. The correlation coefficient was calculated using Pearson correlation ( R ), and p values were determined using a two-sided t -test. e Spatially resolved BRRIAR expression across different tumor types using both 10x Visium and Curio Seeker platforms. BRRIAR -positive cells are depicted as colored dots. f-g Cytokine profiling for granzyme B, granzyme A, IFNγ and CCL5 secreted from HCMV-activated PBMCs (donors; D1-4) after f 48 h exposure to media harvested from T47D cells transfected with dsi-CON or dsi- BRRIAR then treated with <t>5’ppp-dsRNA</t> for 3 h. The dsi-CON is a non-targeting control. Error bars, SEM ( n = 4). Or g 48 h exposure to media harvested from T47D cells transfected with IVT LacZ or IVT BRRIAR for 24 h. Error bars, SEM ( n = 4). p values were determined by two-way ANOVA with Sidak’s test (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). h Proposed model for BRRIAR as a positive regulator of RIG-I activation in ER + breast tumor cells to promote IFN production and support an anti-tumor immune response
    Non Phosphorylated Control Dsrna, supplied by InvivoGen, used in various techniques. Bioz Stars score: 94/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/non phosphorylated control dsrna/product/InvivoGen
    Average 94 stars, based on 32 article reviews
    non phosphorylated control dsrna - by Bioz Stars, 2026-03
    94/100 stars

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    1) Product Images from "BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans"

    Article Title: BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans

    Journal: Molecular Cancer

    doi: 10.1186/s12943-025-02510-8

    BRRIAR expression and immune activation in patient-derived samples. a High-resolution spatial transcriptomics map of one ER + breast tumor generated using the Curio Seeker platform. b Corresponding BRRIAR -positive cell states. c Spatial neighborhood analysis of BRRIAR -positive cells. Bars represent the proportion of neighbouring cell types within a defined radius. Error bars, SD ( n = 13 cells). p value was determined by Student’s t- test (* p < 0.05). d Scatter plot showing correlation between BRRIAR and RIG-I (left panel) or IRF7 (right panel) expression. Each black dot represents an individual cell at the co-expression peak. A linear regression line with its 95% confidence interval (blue shaded area) is overlaid. The correlation coefficient was calculated using Pearson correlation ( R ), and p values were determined using a two-sided t -test. e Spatially resolved BRRIAR expression across different tumor types using both 10x Visium and Curio Seeker platforms. BRRIAR -positive cells are depicted as colored dots. f-g Cytokine profiling for granzyme B, granzyme A, IFNγ and CCL5 secreted from HCMV-activated PBMCs (donors; D1-4) after f 48 h exposure to media harvested from T47D cells transfected with dsi-CON or dsi- BRRIAR then treated with 5’ppp-dsRNA for 3 h. The dsi-CON is a non-targeting control. Error bars, SEM ( n = 4). Or g 48 h exposure to media harvested from T47D cells transfected with IVT LacZ or IVT BRRIAR for 24 h. Error bars, SEM ( n = 4). p values were determined by two-way ANOVA with Sidak’s test (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). h Proposed model for BRRIAR as a positive regulator of RIG-I activation in ER + breast tumor cells to promote IFN production and support an anti-tumor immune response
    Figure Legend Snippet: BRRIAR expression and immune activation in patient-derived samples. a High-resolution spatial transcriptomics map of one ER + breast tumor generated using the Curio Seeker platform. b Corresponding BRRIAR -positive cell states. c Spatial neighborhood analysis of BRRIAR -positive cells. Bars represent the proportion of neighbouring cell types within a defined radius. Error bars, SD ( n = 13 cells). p value was determined by Student’s t- test (* p < 0.05). d Scatter plot showing correlation between BRRIAR and RIG-I (left panel) or IRF7 (right panel) expression. Each black dot represents an individual cell at the co-expression peak. A linear regression line with its 95% confidence interval (blue shaded area) is overlaid. The correlation coefficient was calculated using Pearson correlation ( R ), and p values were determined using a two-sided t -test. e Spatially resolved BRRIAR expression across different tumor types using both 10x Visium and Curio Seeker platforms. BRRIAR -positive cells are depicted as colored dots. f-g Cytokine profiling for granzyme B, granzyme A, IFNγ and CCL5 secreted from HCMV-activated PBMCs (donors; D1-4) after f 48 h exposure to media harvested from T47D cells transfected with dsi-CON or dsi- BRRIAR then treated with 5’ppp-dsRNA for 3 h. The dsi-CON is a non-targeting control. Error bars, SEM ( n = 4). Or g 48 h exposure to media harvested from T47D cells transfected with IVT LacZ or IVT BRRIAR for 24 h. Error bars, SEM ( n = 4). p values were determined by two-way ANOVA with Sidak’s test (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). h Proposed model for BRRIAR as a positive regulator of RIG-I activation in ER + breast tumor cells to promote IFN production and support an anti-tumor immune response

    Techniques Used: Expressing, Activation Assay, Derivative Assay, Generated, Transfection, Control



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    non phosphorylated control dsrna  (InvivoGen)
    94
    InvivoGen non phosphorylated control dsrna
    BRRIAR expression and immune activation in patient-derived samples. a High-resolution spatial transcriptomics map of one ER + breast tumor generated using the Curio Seeker platform. b Corresponding BRRIAR -positive cell states. c Spatial neighborhood analysis of BRRIAR -positive cells. Bars represent the proportion of neighbouring cell types within a defined radius. Error bars, SD ( n = 13 cells). p value was determined by Student’s t- test (* p < 0.05). d Scatter plot showing correlation between BRRIAR and RIG-I (left panel) or IRF7 (right panel) expression. Each black dot represents an individual cell at the co-expression peak. A linear regression line with its 95% confidence interval (blue shaded area) is overlaid. The correlation coefficient was calculated using Pearson correlation ( R ), and p values were determined using a two-sided t -test. e Spatially resolved BRRIAR expression across different tumor types using both 10x Visium and Curio Seeker platforms. BRRIAR -positive cells are depicted as colored dots. f-g Cytokine profiling for granzyme B, granzyme A, IFNγ and CCL5 secreted from HCMV-activated PBMCs (donors; D1-4) after f 48 h exposure to media harvested from T47D cells transfected with dsi-CON or dsi- BRRIAR then treated with <t>5’ppp-dsRNA</t> for 3 h. The dsi-CON is a non-targeting control. Error bars, SEM ( n = 4). Or g 48 h exposure to media harvested from T47D cells transfected with IVT LacZ or IVT BRRIAR for 24 h. Error bars, SEM ( n = 4). p values were determined by two-way ANOVA with Sidak’s test (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). h Proposed model for BRRIAR as a positive regulator of RIG-I activation in ER + breast tumor cells to promote IFN production and support an anti-tumor immune response
    Non Phosphorylated Control Dsrna, supplied by InvivoGen, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/non phosphorylated control dsrna/product/InvivoGen
    Average 94 stars, based on 1 article reviews
    non phosphorylated control dsrna - by Bioz Stars, 2026-03
    94/100 stars
    		  Buy from Supplier

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    BRRIAR expression and immune activation in patient-derived samples. a High-resolution spatial transcriptomics map of one ER + breast tumor generated using the Curio Seeker platform. b Corresponding BRRIAR -positive cell states. c Spatial neighborhood analysis of BRRIAR -positive cells. Bars represent the proportion of neighbouring cell types within a defined radius. Error bars, SD ( n = 13 cells). p value was determined by Student’s t- test (* p < 0.05). d Scatter plot showing correlation between BRRIAR and RIG-I (left panel) or IRF7 (right panel) expression. Each black dot represents an individual cell at the co-expression peak. A linear regression line with its 95% confidence interval (blue shaded area) is overlaid. The correlation coefficient was calculated using Pearson correlation ( R ), and p values were determined using a two-sided t -test. e Spatially resolved BRRIAR expression across different tumor types using both 10x Visium and Curio Seeker platforms. BRRIAR -positive cells are depicted as colored dots. f-g Cytokine profiling for granzyme B, granzyme A, IFNγ and CCL5 secreted from HCMV-activated PBMCs (donors; D1-4) after f 48 h exposure to media harvested from T47D cells transfected with dsi-CON or dsi- BRRIAR then treated with 5’ppp-dsRNA for 3 h. The dsi-CON is a non-targeting control. Error bars, SEM ( n = 4). Or g 48 h exposure to media harvested from T47D cells transfected with IVT LacZ or IVT BRRIAR for 24 h. Error bars, SEM ( n = 4). p values were determined by two-way ANOVA with Sidak’s test (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). h Proposed model for BRRIAR as a positive regulator of RIG-I activation in ER + breast tumor cells to promote IFN production and support an anti-tumor immune response

    Journal: Molecular Cancer

    Article Title: BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans

    doi: 10.1186/s12943-025-02510-8

    Figure Lengend Snippet: BRRIAR expression and immune activation in patient-derived samples. a High-resolution spatial transcriptomics map of one ER + breast tumor generated using the Curio Seeker platform. b Corresponding BRRIAR -positive cell states. c Spatial neighborhood analysis of BRRIAR -positive cells. Bars represent the proportion of neighbouring cell types within a defined radius. Error bars, SD ( n = 13 cells). p value was determined by Student’s t- test (* p < 0.05). d Scatter plot showing correlation between BRRIAR and RIG-I (left panel) or IRF7 (right panel) expression. Each black dot represents an individual cell at the co-expression peak. A linear regression line with its 95% confidence interval (blue shaded area) is overlaid. The correlation coefficient was calculated using Pearson correlation ( R ), and p values were determined using a two-sided t -test. e Spatially resolved BRRIAR expression across different tumor types using both 10x Visium and Curio Seeker platforms. BRRIAR -positive cells are depicted as colored dots. f-g Cytokine profiling for granzyme B, granzyme A, IFNγ and CCL5 secreted from HCMV-activated PBMCs (donors; D1-4) after f 48 h exposure to media harvested from T47D cells transfected with dsi-CON or dsi- BRRIAR then treated with 5’ppp-dsRNA for 3 h. The dsi-CON is a non-targeting control. Error bars, SEM ( n = 4). Or g 48 h exposure to media harvested from T47D cells transfected with IVT LacZ or IVT BRRIAR for 24 h. Error bars, SEM ( n = 4). p values were determined by two-way ANOVA with Sidak’s test (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). h Proposed model for BRRIAR as a positive regulator of RIG-I activation in ER + breast tumor cells to promote IFN production and support an anti-tumor immune response

    Article Snippet: T47D cells were transfected with 3p-hpRNA (0.5 μg/ml; Invivogen) using Lipofectamine 3000, or 5’ppp-dsRNA (1 μg/ml) and its non-phosphorylated control dsRNA (Invivogen) using 6.25 μg of LyoVec transfection reagent (Invivogen) as per the manufacturer’s protocol.

    Techniques: Expressing, Activation Assay, Derivative Assay, Generated, Transfection, Control